Delayed-Onset Hypothesis of Antipsychotic Action

The "delayed onset" of antipsychotic action--an idea whose time has come and gone.

For years, it has been known that the "onset" of the antipsychotic response is "delayed," and this notion is expressed in many major textbooks, informs clinical decisions and has even led to the search for biological markers responsible for this delayed onset. But is the onset of antipsychotic action really delayed? In this review, we bring together data from several recent studies of antipsych...

Reevaluation of the mesolimbic hypothesis of antipsychotic drug action.

Conventional neuroleptic drugs are thought to derive their antipsychotic efficacy through influences on the mesolimbic dopamine (DA) system. In contrast, motor side effects of these drugs are suggested to follow from influences on the nigrostriatal DA system. This conceptualization is based on the assumption that behaviors mediated by the mesolimbic DA system are involved in schizophrenia while...

Focus of Attention: a Challenge on Predicting Constrained Action Hypothesis

Focus of attention instruction has a great influence on performance and learning. The purpose of this study was to examine the predicted constrained action hypothesis in badminton backhand serv. 30 women student participants from physical education classes of University of Kharazmi are selected as sample. Participants are tested in probe task at different stage of serve after identifying base o...

Delayed-onset chloroquine retinopathy.

Delayed-onset chloroquine retinopathy was diagnosed in a patient seven years after cessation of treatment by a total dose of 730 g of chloroquine for rheumatoid arthritis. Visual functions continued to deteriorate after the diagnosis. Periodic examinations by ophthalmoscopy and by functional tests such as EOG and visual fields should be continued in patients at risk of delayed-onset chloroquine...

Delayed onset dystonia.